Whole‐blood Interferon‐γ Release Assay Versus the TST: Newer Not Better

Is Newer Better ? Penn World

This paper sheds light on two problems in the Penn World Table (PWT) GDP estimates. First,we show that these estimates vary substantially across different versions of the PWT despitebeing derived from very similar underlying data and using almost identical methodologies; thatthis variability is systematic; and that it is intrinsic to the methodology deployed by the PWT toest...

Is newer better? Propafenone versus quinidine for conversion of atrial fibrillation.

Newer techniques of carpal tunnel release.

In this article, after a brief account of the history and evolution of endoscopic carpal tunnel release, limited incision techniques, and an overview of the relevant anatomy, the authors describe various methods and instrumentation. The results, complications, and contraindications are noted. Subsequent discussion of the objections to and the special requirements of new techniques leads to judg...

Toxicity of newer versus older antidepressants

Of all the controversies over the different medi cations used in psychiatry, there is probably least dispute about the effectiveness of antidepressants in controlling depressive illness. However, the choice of which antidepressant to use is bedevilled by the spectre of potential toxicity from adverse effects, interactions and overdose. The unwanted effects may vary from mild and tolerable to po...

TST-Negative Individuals Do Not Lack Anti-Mycobacterial Responsiveness

Tuberculin-skin-test (TST) is widely used for the diagnosis of Tuberculosis. Negative TSTs are occasionally found in individuals vaccinated or infected by Mycobacterium tuberculosis. We show that false negative results are due to a lack of the Tuberculin-specific immune response as replacing tuberculin by unselected M. tuberculosis antigens improved the efficiency of the assay. Tuberculosis (TB...